Locally induced hypothermia for treatment of acute ischaemic stroke: A physical feasibility study

38Citations
Citations of this article
34Readers
Mendeley users who have this article in their library.
Get full text

Abstract

During the treatment of stroke by local intra-arterial thrombolysis (LIT) it is frequently possible to pass the blood clot with a micro-catheter, allowing perfusion of brain tissue distally to the occlusion. This possibility allows for new early treatments of ischaemic brain tissue, even before the blood clot has been removed. One potential new approach to preserve brain tissue at risk may be locally induced endovascular hypothermia. Physical parameters such as the required micro-catheter input pressure, output velocity and flow rates, and a heat exchange model, applicable in the case of a micro-catheter placed within a guiding catheter, are presented. Also, a simple cerebral temperature model is derived that models the temperature response of the brain to the perfusion with coolant fluids. Based on this model, an expression has been derived for the time needed to reach a certain cerebral target temperature. Experimental in vitro measurements are presented that confirm the usability of standard commercially available micro-catheters to induce local hypothermia of the brain. If applied in vivo, the model predicts a local cooling rate of ischaemic brain tissue of 300 g of approximately 1°C in 1 min, which is up to a factor 30-times faster than the time-consuming systemic hypothermia via the skin. Systemic body temperature is only minimally affected by application of local hypothermia, thus avoiding many limitations and complications known in systemic hypothermia. © Springer-Verlag 2004.

Cite

CITATION STYLE

APA

Slotboom, J., Kiefer, C., Brekenfeld, C., Ozdoba, C., Remonda, L., Nedeltchev, K., … Schroth, G. (2004). Locally induced hypothermia for treatment of acute ischaemic stroke: A physical feasibility study. Neuroradiology, 46(11), 923–934. https://doi.org/10.1007/s00234-004-1286-z

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free