Cardiac valve calcifi cation prevalence and association with neutrophil-to-lymphocyte ratio in newly diagnosed patients with non-dialysis chronic kidney disease stage 3–5

Abstract

OBJECTIVE: Cardiac valvular calcifi cation (CVC) is the main cause of cardiovascular disease and allcause death in patients with chronic kidney disease (CKD). However, the relationship between Neutrophil lymphocyte ratio (NLR) and CVC in patients with CKD is not clear. In this study, we aimed to investigate the prevalence of CVC in newly diagnosed patients with non-dialysis CKD stage 3–5 and evaluate the correlation between NLR and CVC. METHODS: A total of 483 newly diagnosed patients with non-dialysis CKD stage 3–5 were included. According to the presence of CVC, these patients were retrospectively divided into two groups: CVC group and non-CVC group. RESULTS: CVC was found in 80 patients (16.56 %), 53 (10.97 %) of whom had only aortic valve calcifi cation (AVC), 18 (3.73 %) had mitral valve calcifi cation (MVC), and 9 (1.86 %) had both AVC and MVC. The level of NLR in the CVC group was signifi cantly higher than that in the non-CVC group (p=0.002). Multivariate logistic regression analysis showed that NLR was an independent risk factor for CVC (95% CI 1.017~1.225, p=0.020). ROC curve analysis showed that the area under the curve of NLR for predicting CVC was 0.610 (95% CI 0.543–0.676, p=0.002). The best cut-off point of NLR was 3.340, with a sensitivity of 49.4 % and a specifi city of 70.0 %. CONCLUSION: CVC is not uncommon in newly diagnosed patients with non-dialysis CKD stage 3–5, and NLR is an independent risk factor for CVC (Tab. 4, Fig. 1, Ref. 34). Text in PDF www.elis.sk