Isolated intracranial myeloid sarcoma (MS) is an unusual variant tumor with few cases reported so far in the medical literature. A 29-year-old woman was admitted to our hospital presenting progressive visual loss in the right eye and weight loss (20 kg) without a previous history of hematological disease (HD). Radiologic evaluation showed the evidence of intracranial mass. Histologically, the resected tumor was composed of a uniform population of primitive cells and primarily misdiagnosed as a T-cell non-Hodgkin’s lymphoma (NHL). Chemotherapy with cyclophosphamide, doxorubicin, vinblastine, and pre-dnisone (CHOP) was ineffective. A biopsy and histopathological evaluation were repeated, and immunohistochemical staining revealed the positivity of immature cells to an extensive panel of myeloid markers. These findings were consistent with a diagnosis of MS and bone marrow infiltration. Literature reviews of previous cases were also undertaken.
CITATION STYLE
Xu, G., Zhang, H., Nong, W., Li, C., Meng, L., Liu, C., & Li, F. (2020). Isolated intracranial myeloid sarcoma mimicking malignant lymphoma: A diagnostic challenge and literature reviews. OncoTargets and Therapy, 13, 6085–6092. https://doi.org/10.2147/OTT.S245828
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