Comparison of Resting Full Cycle Ratio with Fractional Flow Reserve in Indian Population

Abstract

Background From the previous studies fractional flow reserve (FFR) was considered best for hemodynamic assessment of bordersline coronary lesions. In literature, previous studies compared instant wave-free ratio (IFR) with resting full cycle ratio (RFR) which concluded that both were equally effective diagnostically. Studies comparing RFR with FFR are still lacking in number.So we have done a prospective study comparing RFR and FFR in predominately chronic stable angina patients, whose coronary angiogram suggestive of borderline coronary lesions.Material and Methods In the department of cardiology in our institution, we have done a prospective study in chronic stable angina patients whose coronary angiogram was suggestive of borderline coronary lesions from March 2019 to June 2019. We recorded RFR value, basal FFR value, and after-adenosine FFR values in borderline coronary lesion patients.Results A total of 33 patients were included in the study. The study population was predominantly male (93.9%). Hypertension was noted in 81.8% and diabetes was noted in 51.5% patients. We compared RFR and FFR by regression analysis; it suggested that both RFR and FFR were significantly correlated, with p = 0.000. This is true even in subgroup analysis of sex (p = 0.001).Conclusion From our study, we conclude that RFR may be used instead of FFR for physiologic assessment of inducible ischemia in borderline coronary artery lesions as it is independent of gender also.