Drug Delivery in Biological Tissues: A Two-Layer Reaction-Diffusion-Convection Model

Abstract

In this paper we present a general model of drug release from a drug delivery device and the subsequent drug transport in biological tissue. In order to study the complete process, a two-phase mathematical model describing the trans-port of a drug between two coupled media of different properties and dimensions is presented. A system of partial differential equations describes both the solid-liquid transfer and diffusion processes in the polymeric substrate as well as diffusion, con-vection and reaction in the tissue layer. The model serves as a useful tool for pro-viding insight into the concurrent effects of the diffusion, convection, solid-liquid transfer and reaction parameters in drug delivery systems.