Nucleolar localization/retention signals

Abstract

Most nuclear proteins are highly dynamic and are able to accumulate inside specific non-membrane-bound domains. A current key question is how macromolecules find and accumulate at nuclear target sites that are not separated from the nucleoplasm by membranes. According to recent findings, nucleolar localization results from nucleolar retention rather than targeting to this compartment. Here, we discuss recent data concerning nucleolar retention via so-called nucleolar localization/retention signals (NoLS/NoRS).