Can molecular methods detect 1% isoniazid resistance in mycobacterium tuberculosis?

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Abstract

Patients may harbor both drug-susceptible and -resistant bacteria, representing heteroresistance. We studied mixtures of isoniazid- resistant and -susceptible Mycobacterium tuberculosis strains. Conventional drug susceptibility testing was the most sensitive method of detection, whereas the line probe assay and sequencing were not able to detect the clinically relevant 1% proportion of resistant bacteria. Copyright © 2013, American Society for Microbiology.

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Folkvardsen, D. B., Svensson, E., Thomsen, V., Rasmussen, E. M., Bang, D., Werngren, J., … Rigouts, L. (2013). Can molecular methods detect 1% isoniazid resistance in mycobacterium tuberculosis? Journal of Clinical Microbiology, 51(5), 1596–1599. https://doi.org/10.1128/JCM.00472-13

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