Differentiation Induction of Human Promyelocytic Leukemia Cells with Colletochlorin B and Its Analogues

Abstract

Colletochlorin analogues are found to be highly potent inducers of differentiation of human promyelocytic leukemia cells. The differentiated cells are morphologically and functionally like mature monocytes. From the activity-structure relationship, it is concluded that a carbonyl residue attached to the benzene ring is essential for both differentiation and cytotoxicity. © 1988, The Pharmaceutical Society of Japan. All rights reserved.