Xenotransplantation of retinal pigment epithelial cells into RCS rats

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Abstract

Purpose: Successful engraftment of retinal pigment epithelial cells (RPE) to treat RPE-related retinopathy will depend, at least in part, on controlling the immune response. In order to understand this process we evaluated the fate of RPE xenografts in the subretinal space, anterior chamber, and subcutis of nonimmunosuppressed Royal College of Surgeons rats. Methods: Freshly isolated adult porcine RPE cells were used as xenografts and implanted when recipients were 17 to 21 days old. The extent of photoreceptor rescue by subretinal transplants was determined by counting the maximum layers of surviving photoreceptor nuclei in histologic sections. Cellular immune response was evaluated by immunohistochemistry. Results: Compared to non- or sham-injected eyes, subretinal xenografts in RPE-transplanted eyes were able to induce a dramatic rescue effect (P

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Grisanti, S., Szurman, P., Jordan, J., Kociok, N., Bartz-Schmidt, K. U., & Heimann, K. (2002). Xenotransplantation of retinal pigment epithelial cells into RCS rats. Japanese Journal of Ophthalmology, 46(1), 36–44. https://doi.org/10.1016/S0021-5155(01)00464-6

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