Tetracycline continues to be used as treatment for a variety of infections due to Gram-positive, Gram-negative, intracellular bacteria, some protozoan infections, and noninfectious conditions [12, 65]. Tetracycline is also an important antibiotic for prophylaxis or treatment either alone or in combination with other antibiotics and for agents of biological terrorism [Bacillus anthracis, Francisella tularensis, and/or Yersinia pestis] [64]. Hughes and Data [29] examined Enterobacteriaceae collected between 1917 and 1954 for tetracycline resistance [Tcr] and found that 2% of the 433 isolates were Tcr, with the first Tcr bacteria found in the 1950s isolates. From this work, it was suggested that the discovery of Tcr bacteria was a relatively recent event and an unintended consequence of tetracycline use in clinical, veterinary, and agricultural experiments since the 1950s.
CITATION STYLE
Roberts, M. C. (2012). Acquired tetracycline resistance genes. In Antibiotic Discovery and Development (Vol. 9781461414001, pp. 543–568). Springer US. https://doi.org/10.1007/978-1-4614-1400-1_16
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