An efficient, solvent free synthesis of some chalcone derivatives and their biological evaluation

Abstract

A solvent free grinding approach was adopted for the synthesis of (E)-1-(2',4'-difluorobiphenyl-4-yl)-3-arylprop-2-en-1-one derivatives. The synthesized derivatives were characterized by elemental analysis, mass, IR and NMR spectrometry. The in vitro antimicrobial activity of the derivatives showed moderate to potent activities against the tested microbes. Molecular docking studies were performed to evaluate the anticancer activities.