Activation-driven T cell death. I. Requirements for de novo transcription and translation and association with genome fragmentation.

  • Ucker D
  • Ashwell J
  • Nickas G
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Abstract

We have observed that stimuli that are mitogenic for normal T cells can induce cell death in transformed T cell hybridomas. "Activation-driven cell death" can be triggered by the presentation of appropriate Ag as well as by treatment with lectins and antibodies specific for the T cell Ag receptor complex and other activation structures on the T cell surface, such as Thy-1 and Ly-6. The activation-driven lethal process is cell autonomous, is associated with a fragmentation of the cell's genome characteristic of the "suicide process" induced in immature T cells by glucocorticoids and in target cells by cytotoxic T lymphocytes, and is dependent upon transcription and translation, presumably associated with the expression of new gene products. We hypothesize that activation-driven cell death may be involved in vivo in the clonal deletion of auto-reactive T cells during T cell ontogeny.

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Ucker, D. S., Ashwell, J. D., & Nickas, G. (1989). Activation-driven T cell death. I. Requirements for de novo transcription and translation and association with genome fragmentation. The Journal of Immunology, 143(11), 3461–3469. https://doi.org/10.4049/jimmunol.143.11.3461

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