Revisiting glucose metabolism in cancer: lessons from a PKM knock-in model

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Abstract

Isoform selection of pyruvate kinase M (PKM), a glycolytic enzyme, influences fates of glucose-derived carbons in cellular metabolic networks. We recently developed novel mouse lines to study PKM isoform function and identified PKM1 as a potential target in a subset of human lung cancers. This work provides new insight into cancer metabolism.

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Sato, T., Morita, M., Nomura, M., & Tanuma, N. (2018). Revisiting glucose metabolism in cancer: lessons from a PKM knock-in model. Molecular and Cellular Oncology, 5(4). https://doi.org/10.1080/23723556.2018.1472054

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