Transmucosal delivery of Docetaxel by mucoadhesive polymeric nanofi bers

Abstract

The aim of the present study is to design a mucoadhesive nano-carrier system which retains at the site of application and maximizes the therapeutic potential of anticancer drug as well as reduces their systemic side eff ects. In the present study PVA nanofi bers of Docetaxel were prepared using electrospinning machine. The resulting nanofi bers were characterized through various parameters such as surface morphology, drug loading, in-vitro drug release, tensile strength, mucoadhesiveness, drug permeability, degree of swelling and anticancer activities against selective cell lines to establish their therapeutics potential. On the basis of various evaluation results, we may conclude that the current approach comprising polymeric nanofi bers can be successfully used for local delivery of anticancer drug.