The prognosis after relapse of high-grade osteosarcoma is poor and complete resection of all tumors is essential for survival. A 6-year old was diagnosed with high-grade osteosarcoma and treated according to the COSS-96 protocol. Within 5 years from initial diagnosis, five osteosarcoma relapses occurred and every time it was possible to achieve complete surgical remission. Additional treatments included chemotherapy and dendritic cell-based cancer immune therapy. Since the end of therapy of the 5th relapse, he is alive for 111/2 years. Our experience further supports that aggressive surgery can help to achieve long-term survival even in patients with multiple osteosarcoma relapses.
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Tamamyan, G., Dominkus, M., Lang, S., Diakos, C., Mittheisz, E., Horcher, E., … Kager, L. (2015). Multiple relapses in high-grade osteosarcoma: When to stop aggressive therapy? Pediatric Blood and Cancer, 62(3), 529–530. https://doi.org/10.1002/pbc.25360