Genomic insights into a robust gamma-aminobutyric acid-producer Lactobacillus brevis CD0817

45Citations
Citations of this article
28Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Lactobacillus brevis CD0817, a strain isolated from a healthy adult gut, was currently the most efficient lactic acid bacterial cell factory for gamma-aminobutyric acid. In this study, the complete genome sequence of CD0817 was determined and compared with some related L. brevis genomes. The CD0817 genome consists of one 2,990,570-bp chromosome and four plasmids. The comparative genomic and phylogenetic analysis revealed that L. brevis CD0817 was not very conserved with low GABA-producing L. brevis strains. A significant divergence was that CD0817 harbors only the gadCA operon whereas the low GABA-producing L. brevis strains contain the operon and gadB. The gadB seemed to only marginally contribute to the accumulation of GABA. The high GABA production ability of CD0817 may be associated with its extraordinary genome.

References Powered by Scopus

Basic local alignment search tool

78851Citations
N/AReaders
Get full text

Gene ontology: Tool for the unification of biology

32140Citations
N/AReaders
Get full text

TRNAscan-SE: A program for improved detection of transfer RNA genes in genomic sequence

9180Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Production of gamma-aminobutyric acid from lactic acid bacteria: A systematic review

305Citations
N/AReaders
Get full text

Gamma-aminobutyric acid and probiotics: Multiple health benefits and their future in the global functional food and nutraceuticals market

182Citations
N/AReaders
Get full text

Glutamate decarboxylase from lactic acid bacteria—a key enzyme in Gaba synthesis

126Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Gao, D., Chang, K., Ding, G., Wu, H., Chen, Y., Jia, M., … Li, H. (2019). Genomic insights into a robust gamma-aminobutyric acid-producer Lactobacillus brevis CD0817. AMB Express, 9(1). https://doi.org/10.1186/s13568-019-0799-0

Readers over time

‘19‘20‘21‘22‘23036912

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 11

69%

Lecturer / Post doc 4

25%

Researcher 1

6%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 8

47%

Biochemistry, Genetics and Molecular Bi... 7

41%

Chemical Engineering 1

6%

Pharmacology, Toxicology and Pharmaceut... 1

6%

Save time finding and organizing research with Mendeley

Sign up for free
0