Renal Physiological Status of Sickle Cell Anemic Patients, District Amravati, MS India

Abstract

Sickle cell anemia is a genetic disorder caused by mutation in globin gene in which serious morbidity and mortality can be resulted. Patients with Sickle cell anemia need regular blood transfusion. Anemia may cause physiological failure of various organ systems. Accumulation of iron due to hemolysis can cause damage to various organs. In the present study, few biochemical indices for renal tubular functions were investigated. In total 67 urine samples from sickle cell anemia patients were studied. Samples were estimated for markers such as Creatinine, Protein, Urea, Sodium (Na+ ), Potassium (K+ ); Uric acid and Specific gravity and Urea. It was observed that many parameters were in abnormal range indicating impaired renal function.