The ratio of monocytes to lymphocytes accuracy as tuberculosis predictor

Abstract

Tuberculosis is one of the top ten death's causes in the world and even cause more deaths than HIV in 2015. In the same years, there are 10.4 million new TB case incidences with case notification rate is 142/100,000 population globally. Monocytes and lymphocytes play an important role in the body's defense mechanism against tuberculosis. Tuberculosis can induce increased monocytes and decreased lymphocytes. The ratio of Monocytes to lymphocytes is expected to be used as predictors of tuberculosis. Therefore, this study was conducted to determine the ratio of monocytes to lymphocytes accuracy as tuberculosis predictor. This diagnostic study was done at dr. Mohammad Hoesin General Hospital Palembang. Samples of this study had been taken from medical records which fulfilled the inclusion and exclusion criteria. The study was analyzed using SPSS version 22.0. The sample of the study was 101 tuberculosis subjects. Most of the subjects were men (70,3%) and were 36-45 years old group (25,7%). The cut-off value of 0,476 allowed the discrimination of tuberculosis with positive bacterial culture from negative bacterial culture, with a sensitivity of 95,1% and a specificity of 70%. Therefore, we concluded that the ratio of monocytes to lymphocytes can be considered as an early predictor marker of tuberculosis.