The role of serum potassium and sodium levels in the development of postpartum hemorrhage. A retrospective study

Abstract

Objectives. Primary postpartum hemorrhage (PPH) represents between cases and controls by Chi-square and U Mannthe first responsible cause of maternal mortality, leading Whitney tests, as appropriate. Logistic regression analysis at least a quarter of deaths during childbirth and in the was used to estimate the odds ratios (ORs) and 95% confidence puerperium. Most cases of PPH occur in women who do intervals (CIs) of PPH associated with Na+, K+ and not have distinct risk factors. Voltage-gated ions channels, Na*K serum levels. In the analysis a crude (simple) and an particularly the potassium channels, play an essential role adjusted model (adjusted for episiotomy and perineal laceration) in contractility regulation of the uterus. The aim of our were used. To evaluate the best PPH predictive study was to identify the possible role of the pre-delivery score, a ROC curve (Receiver Operating Characteristic) was serum sodium (Na+), potassium (K+) electrolytes levels used. and Na*K product in PPH. Results. A lower statistically significant serum level of K+ Methods. We conducted a single-institution retrospective and Na*K product were recorded among the primary PPH study on all patients consecutively referred to our institution cases compared to the control group (p<0.001). The adjusted for spontaneous delivery between 1 January 2011 and ORs (95%CI) for K+ and the product Na*K were 31 December 2018. Among these, patients with PPH were 19.40 (95% CI 2.40-156) and 8.78 (95% CI 1.96-39), respectively. compared to controls patients selected according to specific inclusion-exclusion criteria. All information regarding patient’s Conclusions. A level of electrolytes, particularly for K+ serum characteristics were retrospectively collected, particularly, level, lower than the non-pregnancy threshold/median, pre-delivery blood tests, including serum electrolytes could be considered as a possible pre-delivery risk (such as K+ and Na+) were recorded and compared factor for primary PPH.