UK pneumonectomy outcome study (UKPOS): A prospective observational study of pneumonectomy outcome

60Citations
Citations of this article
52Readers
Mendeley users who have this article in their library.

Abstract

Background: In order to assess the short term risks of pneumonectomy for lung cancer in contemporary practice a one year prospective observational study of pneumonectomy outcome was made. Current UK practice for pneumonectomy was observed to note patient and treatment factors associated with major complications. Methods: A multicentre, prospective, observational cohort study was performed. All 35 UK thoracic surgical centres were invited to submit data to the study. All adult patients undergoing pneumonectomy for lung cancer between 1 January and 31 December 2005 were included. Patients undergoing pleuropneumonectomy, extended pneumonectomy, completion pneumonectomy following previous lobectomy and pneumonectomy for benign disease, were excluded from the study. The main outcome measure was suffering a major complication. Major complications were defined as: death within 30 days of surgery; treated cardiac arrhythmia or hypotension; unplanned intensive care admission; further surgery or inotrope usage. Results: 312 pneumonectomies from 28 participating centres were entered. The major complication incidence was: 30-day mortality 5.4%; treated cardiac arrhythmia 19.9%; unplanned intensive care unit admission 9.3%; further surgery 4.8%; inotrope usage 3.5%. Age, American Society of Anesthesiologists physical status ≥ P3, pre-operative diffusing capacity for carbon monoxide (DLCO) and epidural analgesia were collectively the strongest risk factors for major complications. Major complications prolonged median hospital stay by 2 days. Conclusion: The 30 day mortality rate was less than 8%, in agreement with the British Thoracic Society guidelines. Pneumonectomy was associated with a high rate of major complications. Age, ASA physical status, DLCO and epidural analgesia appeared collectively most associated with major complications. © 2009 Powell et al; licensee BioMed Central Ltd.

References Powered by Scopus

A comparison of the analgesic efficacy and side-effects of paravertebral vs epidural blockade for thoracotomy - A systematic review and meta-analysis of randomized trials

588Citations
N/AReaders
Get full text

Guidelines on the selection of patients with lung cancer for surgery

529Citations
N/AReaders
Get full text

A systematic review of randomized trials evaluating regional techniques for postthoracotomy analgesia

512Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Paravertebral block versus thoracic epidural for patients undergoing thoracotomy

437Citations
N/AReaders
Get full text

Analgesic efficacy and safety of thoracic paravertebral and epidural analgesia for thoracic surgery: A systematic review and meta-analysis

159Citations
N/AReaders
Get full text

A prospective, multicentre, observational cohort study of analgesia and outcome after pneumonectomy

74Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Powell, E. S., Pearce, A. C., Cook, D., Davies, P., Bishay, E., Bowler, G. M. R., … Lee, G. (2009). UK pneumonectomy outcome study (UKPOS): A prospective observational study of pneumonectomy outcome. Journal of Cardiothoracic Surgery, 4. https://doi.org/10.1186/1749-8090-4-41

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 14

52%

Lecturer / Post doc 5

19%

Researcher 5

19%

Professor / Associate Prof. 3

11%

Readers' Discipline

Tooltip

Medicine and Dentistry 33

92%

Agricultural and Biological Sciences 1

3%

Biochemistry, Genetics and Molecular Bi... 1

3%

Social Sciences 1

3%

Save time finding and organizing research with Mendeley

Sign up for free