Role of subgenomic minus-strand RNA in coronavirus replication.

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Abstract

Coronavirus subgenomic minus-strand RNAs (negative-strand copies of the 3' coterminal subgenomic mRNAs) probably function in mRNA amplification by serving as templates for transcription from internal (intergenic) promoters, rather than by faithful (full-length) mRNA replication.

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Brian, D. A., Chang, R. Y., Hofmann, M. A., & Sethna, P. B. (1994). Role of subgenomic minus-strand RNA in coronavirus replication. Archives of Virology. Supplementum, 9, 173–180. https://doi.org/10.1007/978-3-7091-9326-6_17

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