The inter-relationships of the neural basis of rumination and inhibitory control: neuroimaging-based meta-analyses

Abstract

Rumination, as a clinical manifestation and pathogenic factor of depression, has long been the focus of psychological research regarding its causes and ameliorating approaches. Behavioral studies have shown that rumination is related to inhibitory control deficits, which provides ideas for reducing it. However, the neural relationship between them has not been clearly discussed. In this study, we first used multi-level kernel density analysis to conduct two meta-analyses of published functional magnetic resonance imaging studies: one was rumination comprising 17 studies with 180 foci, and the other was inhibitory control comprising 205 studies with 3791 foci. Conjunction analysis was then performed to explore the common brain regions and further decode them through Neurosynth to confirm the cognitive specificity. Results showed that rumination was mainly related to the default mode network (DMN), while inhibitory control was associated with the frontoparietal network (FPN). In addition, the common activation areas were mainly concentrated in the bilateral precuneus, right superior frontal gyrus, bilateral median cingulate, paracingulate gyri, and the left triangular part of inferior frontal gyrus (IFG). Decoding results also revealed they were involved in inhibition, memory retrieval, and self-related processes. Our findings support that rumination is associated with inhibitory control and can be explained neurologically by an antagonistic relationship between the DMN and FPN. In sum, inhibitory control may be related to rumination via inhibiting task-unrelated attention and controlling self-related processing. This research will help us understand and predict rumination from the perspective of inhibitory control and reduce rumination through behavioral training of inhibitory control or the application of neuromodulation techniques to common activation regions.