Background/Aims: We investigated whether an initial neuropsychological assessment could predict rapid progression over 12 months, from amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD). Methods: A longitudinal study compared the neuropsychological profiles of 27 normal controls and 18 aMCI patients at baseline and 12 months. Results: At 12 months, 24 control subjects followed up remained cognitively normal. 7 aMCI patients (6 multiple-domain aMCI and 1 single-domain aMCI) progressed to AD, and 11 were non-progressors. Prognosis was best captured by a combination of associative learning, the paired associate learning task (PAL), and global cognition, the Addenbrooke's Cognitive Examination (ACE). Conclusion: The PAL and ACE can sensitively detect meaningful differences in scores at baseline and may be used as prognostic indicators. Multiple-domain aMCI patients progressed rapidly to AD and may be more usefully labelled as early stage AD. Copyright © 2008 S. Karger AG.
CITATION STYLE
Ahmed, S., Mitchell, J., Arnold, R., Nestor, P. J., & Hodges, J. R. (2008). Predicting rapid clinical progression in amnestic mild cognitive impairment. Dementia and Geriatric Cognitive Disorders, 25(2), 170–177. https://doi.org/10.1159/000113014
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