Interfaces to control cell-biomaterial adhesive interactions

Abstract

Cell adhesion to adsorbed proteins and adhesive sequences engineered on surfaces is crucial to cellular and host responses to implanted devices, biological integration of biomaterials and tissue-engineered constructs, and the performance of biosensors, cell-based arrays, and biotechnological cell-culture supports. This review focuses on interfaces controlling cell-adhesive interactions, with particular emphasis on surfaces controlling protein adsorption, biomimetic substrates presenting bioadhesive motifs, and micropatterned surfaces to engineer adhesive areas. These approaches represent promising strategies to engineer cell-material biomolecular interactions in order to elicit specific cellular responses and enhance the biological performance of materials in biomedical and biotechnological applications. © Springer-Verlag Berlin Heidelberg 2006.