Beckmann Rearrangement of 2-Hydroxy-5-Methylacetophenone Oxime using Vilsmeier-Haack Reagent (POCl3/ DMF): Synthesis of Some New Heterocycles

Abstract

Synthesis of some new heterocyclic derivatives 3a-3g has been reported by the condensation of suitable reagents with malondialdehyde 2. The malondialdehyde 2 was synthesized by Beckmann rearrangement of 2-hydroxy-5-methylacetophenone oxime 1 using Vilsmeier-Haack reagent (POCl3/ DMF), followed by cyclization. © 2010, by Walter de Gruyter GmbH & Co. All rights reserved.