Efficcacy of Lantana camara Linn. leaf extracts ointment on dermal wound healing were infected with Staphylococcus epidermidis

Abstract

Background: Dermal infections by Staphylococcus epidermidis can cause problems for patients. Antibiotic resistance have been reported to treat the bacteria, therefore need to develop new drugs, among others sourced from herbs. For this purpose, study is needed to find an efficacy of Lantana camara Linn. leaf extract ointment on dermal wound healing were infected with S. epidermidis.Methods: Wistar rats divided into 4 groups randomly. Group I=dermal wounded, infected with S. epidermidis, untreated. Group II=dermal wounded, infected with S. epidermidis, treated with L. camara Linn. leaf extract ointment 5%. Group III=dermal wounded, infected with S. epidermidis, treated with L. camara Linn. leaf extract ointment 10%. Group IV=dermal wounded, infected with S. epidermidis, treated with sodium fusidate 2%. Bacterial colonies number observed on 6 days, while the quality of wound healing, measurement of DNA and protein levels on 6, 14 and 18 days. Mean ± SD between groups were analyzed by ANOVA.Results: Wound healing in group II qualitatively better than group I, III and IV. Bacterial colonies number in group II was lower than groups I, III and IV (p<0.05), whereas DNA and protein levels was higher in group II compare to groups I, III and IV (p<0.05). On 6, 14 and 18 days observations there are trend similarly ie DNA levels decreased, conversely protein levels increased.Conclusions: L. camara Linn. leaf extract ointment 5% more effective than 10% on dermal wound healing.