Catalytic one-pot, three-component acyl-strecker reaction

Abstract

Different aldehydes and amines react with acyl cyanides in the presence of a catalytic amount of the Schreiner thiourea catalyst to give the corresponding N-acyl amino nitriles in high yields. The scope of the reaction is broad and both aromatic and aliphatic aldehydes and amines can readily be used. © Georg Thieme Verlag Stuttgart.