Exposure to urban nanoparticles at low PM 1 concentrations as a source of oxidative stress and inflammation

7Citations
Citations of this article
37Readers
Mendeley users who have this article in their library.

Abstract

Exposures to fine particulate matter (PM 1) have been associated with health impacts, but the understanding of the PM 1 concentration-response (PM 1 -CR) relationships, especially at low PM 1 , remains incomplete. Here, we present novel data using a methodology to mimic lung exposure to ambient air (2 < PM1< 60 μ g m - 3), with minimized sampling artifacts for nanoparticles. A reference model (Air Liquid Interface cultures of human bronchial epithelial cells, BEAS-2B) was used for aerosol exposure. Non-linearities observed in PM 1 -CR curves are interpreted as a result of the interplay between the aerosol total oxidative potential (OP t) and its distribution across particle size (d p). A d p -dependent condensation sink (CS) is assessed together with the distribution with d p of reactive species. Urban ambient aerosol high in OP t , as indicated by the DTT assay, with (possibly copper-containing) nanoparticles, shows higher pro-inflammatory and oxidative responses, this occurring at lower PM 1 concentrations (< 5 μ g m - 3). Among the implications of this work, there are recommendations for global efforts to go toward the refinement of actual air quality standards with metrics considering the distribution of OP t with d p also at relatively low PM 1 .

Cite

CITATION STYLE

APA

Costabile, F., Gualtieri, M., Rinaldi, M., Canepari, S., Vecchi, R., Massimi, L., … Decesari, S. (2023). Exposure to urban nanoparticles at low PM 1 concentrations as a source of oxidative stress and inflammation. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-45230-z

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free