Thyroid Hormone Profile in Patients Ingesting Soft Gel Capsule or Liquid Levothyroxine Formulations with Breakfast

22Citations
Citations of this article
20Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Background. Recently, it has been shown that liquid L-T4 formulation can be ingested with breakfast. This study looked to extend these findings by investigating whether a soft gel capsule formulation of L-T4 could also be ingested at breakfast time. Methods. 60 patients (18-65 yrs), previously submitted to thyroidectomy for proven benign goitre in stable euthyroidism receiving liquid L-T4 therapy ingested with breakfast, were enrolled. TSH, fT4, and fT3 levels were assessed in all the patients who were switched from liquid L-T4 to a soft gel capsule formulation at the same dosage of L-T4. After 6 months, TSH, fT4, and fT3 levels were determined again. Results. There were no differences in TSH levels, but fT3 and fT4 levels during treatment with the soft gel capsule were significantly lower than those at enrolment with the liquid L-T4 formulation (TSH median (min-max): 1.9 (0.5-4.0) versus 2.2 (0.5-4.5) mIU/L, fT3: 2.5 (2.4-3.1) versus 2.7 (2.4-3.3) pg/mL, p < 0.05, and fT4: 9.9 (8.0-13) versus 10.6 (8.6-13.8) pg/mL, p < 0.0001). Conclusion. Both liquid and soft gel formulations of L-T4 can be taken with breakfast. However, liquid L-T4 would be the preferred formulation for patients in whom even small changes in fT4 and fT3 levels are to be avoided.

References Powered by Scopus

The colorado thyroid disease prevalence study

2151Citations
N/AReaders
Get full text

Guidelines for the treatment of hypothyroidism: Prepared by the American thyroid association task force on thyroid hormone replacement

1253Citations
N/AReaders
Get full text

Clinical practice guidelines for hypothyroidism in adults: Cosponsored by the american association of clinical endocrinologists and the American thyroid association

803Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Levothyroxine therapy: Changes of TSH levels by switching patients from tablet to liquid formulation. A systematic review and meta-analysis

49Citations
N/AReaders
Get full text

Levothyroxine interactions with food and dietary supplements–a systematic review

43Citations
N/AReaders
Get full text

New Formulations of Levothyroxine in the Treatment of Hypothyroidism: Trick or Treat?

37Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Cappelli, C., Pirola, I., Gandossi, E., Cristiano, A., Daffini, L., Agosti, B., … Castellano, M. (2016). Thyroid Hormone Profile in Patients Ingesting Soft Gel Capsule or Liquid Levothyroxine Formulations with Breakfast. International Journal of Endocrinology, 2016. https://doi.org/10.1155/2016/9043450

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 6

46%

Researcher 4

31%

Professor / Associate Prof. 2

15%

Lecturer / Post doc 1

8%

Readers' Discipline

Tooltip

Medicine and Dentistry 6

50%

Pharmacology, Toxicology and Pharmaceut... 3

25%

Biochemistry, Genetics and Molecular Bi... 2

17%

Agricultural and Biological Sciences 1

8%

Article Metrics

Tooltip
Social Media
Shares, Likes & Comments: 50

Save time finding and organizing research with Mendeley

Sign up for free