Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine

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Abstract

Objectives. The present study was carried out to determine whether inhalation of hydrogen (H2) gas protects myocardium against ischemia-reperfusion (I/R) injury in swine. Design. In anesthetized open-chest swine, myocardial stunning was produced by 12-minute occlusion of left anterior descending coronary artery (LAD) followed by 90-minute reperfusion in the first study. Group A inhaled 100% oxygen, and group B inhaled 2% H2 plus 98% oxygen during ischemia and reperfusion. In the second study, myocardial infarction was produced by 40-minute occlusion of LAD followed by 120-minute reperfusion. Group C inhaled 100% oxygen during ischemia and reperfusion. Group D inhaled 2% H2 plus 98% oxygen. Group E inhaled 4% H2 plus 96% oxygen. Results. The change of segment shortening (%SS) from baseline at 90 minutes after reperfusion in group B was 74±13 (mean ± SD) %, which was significantly higher than that in group A (48±15%). Myocardial infarct size in group E (32±10%), but not in group D (40±9%) was smaller than that in group C (46±6%). Conclusions. Inhalation of 2% H2 gas improves myocardial stunning, and inhalation of 4% but not 2% H2 gas reduces myocardial infarct size in swine. © 2012 Informa Healthcare.

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Sakai, K., Cho, S., Shibata, I., Yoshitomi, O., Maekawa, T., & Sumikawa, K. (2012). Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine. Scandinavian Cardiovascular Journal, 46(3), 183–188. https://doi.org/10.3109/14017431.2012.659676

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