Inducer-specific regulators of tumor necrosis factor alpha production

Abstract

Novel potent regulators of tumor necrosis factor alpha (TNF-α) production by a human promyelocytic leukemia cell line, HL-60, were prepared. All the compounds showed inducer-specific and bidirectional regulation of TNF-α production, i.e., they enhanced 12-O-tetradecanoylphorbol-13-acetate- induced TNF-α production, while they inhibited okadaic acid-induced one.