Preparation of HA-mineralized CS/PLA composites nanofiber GBR mats

Abstract

In this work, a composited guided bone regeneration (GBR) membrane made of hydroxyapatite (HA) mineralized on electrospun chitosan (CS)-coated poly (lactic acid) (PLA) nanofiber mat was prepared and compared in terms of mineralization characteristics. Fabrication parameters of CS-co-PLA nanofibers and mineralized of calcium phosphate crystals were discussed in details. Fourier transform infrared spectroscopy (FTIR) showed a compositions of CS/PLA mixture and X-ray diffraction results further indicated that the composition of the deposited mineral was a mixture of dicalcium phosphate dehydrates and apatite. These results indicated the HA crystals can be simple mineralized on CS/PLA nanofiber mat which provides notonly better geometric properties but also biological functions for GBR application.