We propose a novel connectivity measure between brain regions using diffusion-weighted MRI. This connectivity measure is based on optimal sub-Finslerian geodesic front propagation on the 5D base manifold of (3D) positions and (2D) directions, the so-called sphere bundle. The advantage over spatial front propagations is that it prevents leakage at omnipresent crossings. Our optimal fronts on the sphere bundle are geodesically equidistant w.r.t. an asymmetric Finsler metric, and can be computed with existing anisotropic fast-marching methods. Comparisons to ground truth connectivities provided by the ISBI-HARDI challenge reveal promising results, both quantitatively and qualitatively. We also apply the connectivity measures to real data from the Human Connectome Project.
CITATION STYLE
Portegies, J., Meesters, S., Ossenblok, P., Fuster, A., Florack, L., & Duits, R. (2019). Brain Connectivity Measures via Direct Sub-Finslerian Front Propagation on the 5D Sphere Bundle of Positions and Directions. In Mathematics and Visualization (pp. 309–321). Springer Heidelberg. https://doi.org/10.1007/978-3-030-05831-9_24
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