Assessment of sirolimus-eluting coronary stent implantation with aspirin plus low dose ticlopidine administration - One year results from CYPHER stent Japan Post-Marketing Surveillance Registry (J-PMS)

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Abstract

Background: Clinical data of sirolimus-eluting stent (SES) implantation are under investigation in Japan. Methods and Results: The CYPHER stent Japan Post-Marketing Surveillance Registry (J-PMS) was conducted at 50 medical centers to assess the results of SES in daily clinical practice exclusively under aspirin plus low dose ticlopidine (200 mg/day). A total of 2,459 lesions in 2,054 patients were treated with 3,285 SES. The mean age was 67.1±10.1 years, 75.6% were men and 43.3% were diabetics. Intravascular ultrasound was used in 77.2%. The 8-month angiographic and 1-year clinical follow-up data were available in 85.4% and 96.8%, respectively. Quantitative coronary angiography showed the reference vessel diameter and percentage diameter stenosis at baseline were 2.47±0.58 mm and 72.0±16.1%. The 8-month late loss was 0.20±0.50 mm. The major adverse cardiovascular events at 1 year was 7.3%; cardiac death: 1.1%, myocardial infarction (MI): 1.2%, and target lesion revascularization (TLR): 4.2%. The rates of definite and probable stent thrombosis at 1 year were 0.30% and 0.10%, respectively. Hemodialysis was the strongest predictor of death/MI or TLR. Conclusions: J-PMS showed the effectiveness of SES implantation under aspirin plus low dose ticlopidine administration at 1 year, although further studies are necessary to demonstrate the safety.

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Ikari, Y., Kotani, J., Kozuma, K., Kyo, E., Nakamura, M., & Yokoi, H. (2009). Assessment of sirolimus-eluting coronary stent implantation with aspirin plus low dose ticlopidine administration - One year results from CYPHER stent Japan Post-Marketing Surveillance Registry (J-PMS). Circulation Journal, 73(6), 1038–1044. https://doi.org/10.1253/circj.CJ-08-0732

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