Polymorphisms in various coagulation genes in black South African women with placental abruption

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Abstract

This pilot study examined Factor V Leiden (R506Q), prothrombin (20210G → A), thrombomodulin (A455V) and MTHFR (677C → T) in 100 Zulu-speaking black South African women with placental abruption and 217 controls. The Factor V Leiden and prothrombin variant gene alleles were not detected in either patient or control groups. The thrombomodulin polymorphic variant was not seen in the patient group but three heterozygotes (1%) were found in the controls. No homozygotes for the MTHFR T677 variant were detected in the patients but two (1%) were noted in the controls; the normal and heterozygote genotype and allele frequencies for this polymorphism were similar in the two groups.

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Hira, B., Pegoraro, R. J., Rom, L., Govender, T., & Moodley, J. (2002). Polymorphisms in various coagulation genes in black South African women with placental abruption. BJOG: An International Journal of Obstetrics and Gynaecology, 109(5), 574–575. https://doi.org/10.1111/j.1471-0528.2002.01528.x

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