Globally, antibiotic resistance continues to be an increasing problem. The emergence of methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and extended spectrum β-lactamase-producing Enterobacteriaceae has seriously reduced the number of empirical agents suitable for selected indications. Increasing Gram-negative resistance has also negatively impacted the physician's alternatives when choosing adequate initial therapy; increased reliance on the carbapenem class as empirical agents has led to the emergence of multidrug resistance in non-enteric Gram-negative bacilli. There is a critical need for new, broad-spectrum alternatives to the currently available broad-spectrum agents. © 2008 Elsevier Ltd. All rights reserved.
Isturiz, R. (2008). Global resistance trends and the potential impact on empirical therapy. International Journal of Antimicrobial Agents, 32(SUPPL. 4). https://doi.org/10.1016/S0924-8579(09)70003-2