Comparative in vitro activities of DU-6859A, levofloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against 387 aerobic and anaerobic bite wound isolates

Abstract

The activities of DU-6859a, levofloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against bite wound isolates were determined by the agar dilution method. DU-6859a was the most active compound (MICs, ≤0.125 μg/ml) against all Pasteurella species, Staphylococcus aureus, and streptococci; anaerobes were susceptible to ≤0.5 μg/ml, except fusobacteria, which were susceptible to ≤2 μg/ml. Against aerobes, levofloxacin was more active than ofloxacin (MIC at which 90% of isolates are inhibited [MIC90], ≤1.0 μg/ml for both) and sparfloxacin and ciprofloxacin were also active (MIC90, ≤0.25 and ≤1 μg/ml, respectively).