The role of constitutive nitric-oxide synthase in ultraviolet B light-induced nuclear factor κB activity

Abstract

Background: Early activation of NF-κB upon UVB irradiation is through a noncanonical eIF2-dependent IκB reduction pathway. Results: Inhibition of constitutive nitric-oxide synthase inhibited UVB-induced NF-κB activation. Conclusion: Constitutive nitric-oxide synthase is required for NF-κB activation. Significance: Learning the regulation of NF-κB upon UVB irradiation is critical for understanding the initiation and development of UVB-induced tumorigenesis.