The hydrogel template strategy was previously developed to fabricate homogeneous polymeric microparticles. Here, we demonstrate the versatility of the hydrogel template strategy for the development of nanowafer-based ocular drug delivery systems. We describe the fabrication of dexamethasone-loaded nanowafers using polyvinyl alcohol and the instillation of a nanowafer on a mouse eye. The nanowafer, a small circular disk, is placed on the ocular surface, and it releases a drug as it slowly dissolves over time, thus increasing ocular bioavailability and enhancing efficiency to treat eye injuries.
CITATION STYLE
Shin, C. S., Marcano, D. C., Park, K., & Acharya, G. (2017). Application of hydrogel template strategy in ocular drug delivery. In Methods in Molecular Biology (Vol. 1570, pp. 279–285). Humana Press Inc. https://doi.org/10.1007/978-1-4939-6840-4_19
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