Disrupted regulation of social exclusion in alcohol-dependence: An fmri study

88Citations
Citations of this article
156Readers
Mendeley users who have this article in their library.

Abstract

Alcohol-dependence is associated with cognitive and biological alterations, and also with interpersonal impairments. Although overwhelming in clinical settings and involved in relapse, these social impairments have received little attention from researchers. Particularly, brain alterations related to social exclusion have not been explored in alcohol-dependence. Our primary purpose was to determine the neural correlates of social exclusion feelings in this population. In all, 44 participants (22 abstinent alcohol-dependent patients and 22 paired controls) played a virtual game (cyberball) during fMRI recording. They were first included by other players, then excluded, and finally re-included. Brain areas involved in social exclusion were identified and the functional connectivity between these areas was explored using psycho-physiological interactions (PPI). Results showed that while both groups presented dorsal anterior cingulate cortex (dACC) activations during social exclusion, alcohol-dependent participants exhibited increased insula and reduced frontal activations (in ventrolateral prefrontal cortex) as compared with controls. Alcohol-dependence was also associated with persistent dACC and parahippocampal gyrus activations in re-inclusion. PPI analyses showed reduced frontocingulate connectivity during social exclusion in alcohol-dependence. Alcohol-dependence is thus linked with increased activation in areas eliciting social exclusion feelings (dACC-insula), and with impaired ability to inhibit these feelings (indexed by reduced frontal activations). Altered frontal regulation thus appears implied in the interpersonal alterations observed in alcohol-dependence, which seem reinforced by impaired frontocingulate connectivity. This first exploration of the neural correlates of interpersonal problems in alcohol-dependence could initiate the development of a social neuroscience of addictive states. © 2012 American College of Neuropsychopharmacology. All rights reserved.

References Powered by Scopus

Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI

2873Citations
N/AReaders
Get full text

Does rejection hurt? An fMRI study of social exclusion

2796Citations
N/AReaders
Get full text

Psychophysiological and modulatory interactions in neuroimaging

2556Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Neuroimaging Impaired Response Inhibition and Salience Attribution in Human Drug Addiction: A Systematic Review

361Citations
N/AReaders
Get full text

Time to connect: Bringing social context into addiction neuroscience

214Citations
N/AReaders
Get full text

Psychosocial versus physiological stress - Meta-analyses on deactivations and activations of the neural correlates of stress reactions

203Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Maurage, P., Joassin, F., Philippot, P., Heeren, A., Vermeulen, N., Mahau, P., … De Timary, P. (2012). Disrupted regulation of social exclusion in alcohol-dependence: An fmri study. Neuropsychopharmacology, 37(9), 2067–2075. https://doi.org/10.1038/npp.2012.54

Readers over time

‘12‘13‘14‘15‘16‘17‘18‘19‘20‘21‘22‘23‘24‘2507142128

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 80

70%

Researcher 17

15%

Professor / Associate Prof. 15

13%

Lecturer / Post doc 2

2%

Readers' Discipline

Tooltip

Psychology 62

64%

Neuroscience 13

13%

Medicine and Dentistry 13

13%

Agricultural and Biological Sciences 9

9%

Article Metrics

Tooltip
Social Media
Shares, Likes & Comments: 2

Save time finding and organizing research with Mendeley

Sign up for free
0