Recent developments in the synthesis of fluorine-containing β-amino acids and β-lactams

Abstract

Fluorine-containing β-amino acids and β-lactams have attracted appreciable attention due to their wide application in organic chemistry, drug discovery, and protein biology. Accordingly, the development of efficient synthetic methods is of considerable interest in academia and industry. The synthesis and resolution are achieved. This review briefly summarizes the recent development in the methodologies for the synthesis of fluorine-containing β-amino acids and β-lactams with classification by the species of the fluorine-containing β-amino acids (α-fluorinated β-amino acids, α-trifluoromethyl β-amino acids, and β-trifluoromethyl β-amino acids). © 2013 Chinese Chemical Society & SIOC, CAS.