Complete Genome Sequence of Actinomadura Parvosata Subsp. Kistnae , A Rich Source of Novel Natural Product (Bio-)Chemistry

  • Kusserow K
  • Gulder T
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Abstract

The soil dwelling actinomycete strain Actinomadura parvosata subsp. kistnae is the producer of the antiviral antibiotics kistamicin A and B. Genome sequencing and bioinformatic analysis revealed the presence of the kistamycin biosynthetic gene cluster responsible for the formation of these non-ribosomal peptides as well as an impressive number of yet uncharacterized biosynthetic pathways. This includes polyketide, ribosomal and non-ribosomal peptide and a large number of terpenoid biosynthetic loci encoding yet unknown natural products. The genomic data of this strain is thus a treasure trove for genome mining for novel functional metabolites and new biocatalysts.

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Kusserow, K., & Gulder, T. A. M. (2017). Complete Genome Sequence of Actinomadura Parvosata Subsp. Kistnae , A Rich Source of Novel Natural Product (Bio-)Chemistry. Journal of Genomics, 5, 75–76. https://doi.org/10.7150/jgen.19673

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