Role of TRPV4 in the Diagnosis and Treatment of Helicobacter pylori Infection in Children with Duodenal Ulcers

2Citations
Citations of this article
17Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Duodenal ulcer seriously affects the quality of life and life safety of children, but the pathogenesis of children with duodenal ulcer is still unclear. As an important second messenger in the body, Ca2+ participates in the physiological and pathological processes of various diseases. Therefore, transient receptor potential vanilloid type 4 (TRPV4) as one of the channels that mediate Ca2+ has attracted widespread attention in recent years. Here, we found that TRPV4 is highly expressed in children with duodenal ulcer and has good diagnostic value through specimens of children with duodenal ulcer, and animal experiments have proved that TRPV4 is also highly expressed in duodenal ulcer mice. In addition, TRPV4 can enhance intestinal permeability, thereby promoting further infiltration of inflammatory factors. In summary, these results indicate that TRPV4 is involved in the occurrence and development of duodenal ulcer. Therefore, this study provides the diagnostic and therapeutic value of TRPV4 in children with duodenal ulcer.

References Powered by Scopus

Helicobacter pylori infection

2349Citations
N/AReaders
Get full text

Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut

530Citations
N/AReaders
Get full text

Intestinal barrier in inflammatory bowel disease

312Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Neutrophil-derived S100A8/A9 promotes apoptosis of intestinal epithelial cells in children with duodenal ulcers

1Citations
N/AReaders
Get full text

The Role of the TRPV4 Channel in Intestinal Physiology and Pathology

0Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Li, C., Cheng, R., Li, L., Chen, M., & Wu, C. (2022). Role of TRPV4 in the Diagnosis and Treatment of Helicobacter pylori Infection in Children with Duodenal Ulcers. BioMed Research International, 2022. https://doi.org/10.1155/2022/2777882

Readers over time

‘22‘23‘24‘2502468

Readers' Seniority

Tooltip

Lecturer / Post doc 2

100%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 3

60%

Medicine and Dentistry 2

40%

Save time finding and organizing research with Mendeley

Sign up for free
0