Nephrotoxicity of 6315-S (FLOMOXEF) In Rabbits

Abstract

The nephrotoxic potential of 6315-S (flomoxef) was evaluated in four male rabbits after a single i. v. administration at 1,000 mg/kg (via the v. retroauricularis), and compared with that of cefazolin sodium (CEZ). The effects on urinalysis and plasma chemistry parameters were determined. Histological examinations of kidney tissues of all animals were performed after 72 h. 6315-S produced foci of proximal tubular necrosis without showing any adverse effects on urinalysis or plasma chemistry parameters. On the other hand, CEZ caused a marked increase in BUN and creatinine, and all animals showed moderate or severe necrosis in proximal tubules accompanied by protein and casts in urine. The data indicate that 6315-S has less nephrotoxic potential than CEZ, a compound which does not produce significant nephrotoxicity in human chemotherapy. © 1987, Japanese Society of Chemotherapy. All rights reserved.