Measuring evolutionary rates of proteins in a structural context

  • Sydykova D
  • Jack B
  • Spielman S
  • et al.
Citations of this article
Mendeley users who have this article in their library.


We describe how to measure site-specific rates of evolution in protein-coding genes and how to correlate these rates with structural features of the expressed protein, such as relative solvent accessibility, secondary structure, or weighted contact number. We present two alternative approaches to rate calculations: One based on relative amino-acid rates, and the other based on site-specific codon rates measured as dN / dS . We additionally provide a code repository containing scripts to facilitate the specific analysis protocols we recommend.




Sydykova, D. K., Jack, B. R., Spielman, S. J., & Wilke, C. O. (2018). Measuring evolutionary rates of proteins in a structural context. F1000Research, 6, 1845.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free