We analyzed the cost-effectiveness of hepatitis A vaccination regimens using a mathematical simulation model. Passive immunization and two active vaccination strategies (with and without prior screening) were compared with 'doing nothing.' Hepatitis A antibodies were determined in 2,325 Dutch marines; other input data were retrieved from published and unpublished sources. The prevalence of hepatitis A antibody was 14%. Screening before vaccination was identified as appropriate at a prevalence > 20%. Passive immunization was the cheapest prevention for a single 6-month deployment per 10 years. The inactivated vaccine containing 1,440 enzyme-linked immunosorbent assay units without prior screening was identified as the best option for more frequent deployments. It was cost-saving with two or more missions per 10 years. A 5.3% hepatitis A attack rate validated the investment for this policy. Overall, immunization with inactivated hepatitis A vaccine without prior screening proved to be the optimum strategy for troops at regular risk.
CITATION STYLE
Buma, A. H., Beutels, P., Van Damme, P., Tormans, G., Van Doorslaer, E., & Leentvaar-Kuijpers, A. (1998). An economic evaluation of hepatitis A vaccination in Dutch military personnel. Military Medicine, 163(8), 564–567. https://doi.org/10.1093/milmed/163.8.564
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