Oxidative stress regulation in Giardia lamblia

Abstract

Giardia lamblia is a common gut parasite that infects the human gastrointestinal tract and causes 280 million cases of diarrhea every year. There are several reports on oxidative stress management in G. lamblia and how Giardia establishes its pathogenesis against the high oxygen tension in the gut. Here we have discussed about four oxidative stress-generating conditions which are actually mimicking the environment where Giardia resides. This chapter explored the fact that pyruvate, a crucial intermediary metabolite, acts as an antioxidant. This chapter has also elucidated the conserved and stress-specific responses of the trophozoite under different stressed conditions. The chapter will unveil the information generated by proteomic study. The chapter will also reveal how oxidative stress regulation works in Giardia trophozoites.