Epidemiology of osteonecrosis of the Jaws from antiresorptive treatment

Abstract

Osteonecrosis of the jaws (ONJ), also called “dead jawbone,” is a complication of bisphosphonate (BP) and denosumab treatment of osteoporosis. The first cases associated with bisphosphonate were reported in 2003, and in recent years a significant knowledge has evolved. The incidence is low, but those affected may suffer from pain, loss of gums and teeth, and thus significant loss of masticatory function. This chapter gives an overview of classification as it relates to epidemiology and of the epidemiology of this important condition.