Mulberry (Morus alba L.) root bark (MRB) was extracted using methanol and the extracts were subjected to tests of anti-inflammatory effects. The ethyl acetate fraction demonstrated the best anti-inflammatory effects. Purified compounds, sanggenon B, albanol B and sanggenon D, showed inhibitory effects on NO production in LPS-stimulated RAW264.7 cells and albanol B demonstrated the best anti-inflammatory effects. Regarding the underlying molecular mechanisms, further investigations showed that treatments with Albanol B reduced production of pro-inflammatory cytokines and decreased expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). These results would contribute to development of novel anti-inflammatory drugs from MRB.
CITATION STYLE
Wu, Y. X., Kim, Y. J., Kwon, T. H., Tan, C. P., Son, K. H., & Kim, T. (2020). Anti-inflammatory effects of mulberry (Morus alba L.) root bark and its active compounds. Natural Product Research, 34(12), 1786–1790. https://doi.org/10.1080/14786419.2018.1527832
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