Metabolic status and resistin in chronic schizophrenia over a 2-year period with continuous atypical antipsychotics

5Citations
Citations of this article
29Readers
Mendeley users who have this article in their library.

Abstract

Common adverse effects of atypical antipsychotic treatments for schizophrenia are weight gain and lipid metabolism abnormality. We aimed to identify the signs of metabolic problems with continuous atypical antipsychotic treatment for schizophrenia over a 2-year period. The participants were 68 schizophrenic patients (29 males, 39 females; ages 53.4 ± 13.5 years old). Changes in carbohydrate metabolism and changes in physical characteristics were studied over a 2-year period. In addition, functional single nucleotide polymorphisms in the transcriptional regulatory region of the resistin gene were examined. We found no changes in the mental state of the participants over a 2-year period. Patients did show a significant decrease in total cholesterol and hemoglobin A1c levels, although physical changes such as body mass index and abdominal girth, were not observed. The amount of resistin may not be associated with mental states and physical parameters. We could not find physical factors related to metabolic changes of antipsychotics in this 2-year study. However, several psychological factors, such as health-related thoughts and behaviors, should be studied in the future. © 2015, SAGE Publications. All rights reserved.

References Powered by Scopus

Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction

6170Citations
N/AReaders
Get full text

The hormone resistin links obesity to diabetes

4198Citations
N/AReaders
Get full text

Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: A multiple-treatments meta-analysis

2101Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Plasma metabonomics study of first-Episode schizophrenia treated with olanzapine in female patients

15Citations
N/AReaders
Get full text

Amisulpride switching in schizophrenic patients who showed suboptimal effect and/or tolerability to current antipsychotics in a naturalistic setting: An explorative study

10Citations
N/AReaders
Get full text

Is obstructive sleep apnea the missing link between metabolic syndrome and second-generation antipsychotics: Preliminary study

5Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Kawabe, K., Ochi, S., Yoshino, Y., Mori, Y., Onuma, H., Osawa, H., … Ueno, S. I. (2015). Metabolic status and resistin in chronic schizophrenia over a 2-year period with continuous atypical antipsychotics. Therapeutic Advances in Psychopharmacology, 5(5), 271–277. https://doi.org/10.1177/2045125315596697

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 9

82%

Professor / Associate Prof. 2

18%

Readers' Discipline

Tooltip

Medicine and Dentistry 9

64%

Psychology 3

21%

Pharmacology, Toxicology and Pharmaceut... 1

7%

Neuroscience 1

7%

Save time finding and organizing research with Mendeley

Sign up for free